Growth factor attenuation of IFNγ-mediated hepatocyte apoptosis requires p21waf−1
نویسندگان
چکیده
منابع مشابه
Hepatocyte Growth Factor
Hepatocyte growth factor (HGF) exerts biological activity through the Met receptor tyrosine kinase. HGF plays essential roles in the embryonic development of the liver and placenta, and in the migration of myogenic precursor cells. In mature tissues, HGF plays roles in tissue protection and regeneration, including in the liver and kidney. HGF participates in invasion, metastasis, and drug resis...
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14 Lp16-PSP from Lentinula edodes strain C91-3 has been reported previously in our laboratory to have selective 15 cytotoxic activity against a panel of human cell lines. Herein, we have used several parameters in order to 16 characterize the Lp16-PSP-induced cell death using HL-60 as model cancer. The results of phase contrast 17 microscopy, nuclear examination, DNA fragmentation detection and...
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Intestinal epithelial cells rest on a fibroblast sheath. Thus, factors produced by these fibroblasts may influence epithelial function in a paracrine fashion. We examined modulation of intestinal epithelial function by one such fibroblast product, scatter factor/ hepatocyte growth factor (HGF/SF). This effect was studied in vitro by using model T84 intestinal epithelial cells. When applied to c...
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In several types of cells, the activation of the receptor tyrosine kinase c-Met by its ligand hepatocyte growth factor (HGF) requires the coreceptor CD44v6. The CD44 extracellular domain is necessary for c-Met autophosphorylation, whereas the intracellular domain is required for signal transduction. We have already shown that the CD44 cytoplasmic tail recruits ezrin, radixin and moesin (ERM) pr...
متن کاملAnalysis of Soluble Mesenchymal-Epithelial Transition Factor and Hepatocyte Growth Factor Serum Levels in Children With Autism Spectrum Disorder
Background: Hepatocyte Growth Factor (HGF) and its receptor, Mesothelial-Epithelial Transition (cMet) factor signaling, play an essential role in controlling synaptogenesis. Objectives: Because of the vital role of HGF and Met signaling in synaptogenesis and spatial learning function of the brain’s hippocampal region, we aimed to study the HGF and soluble cMet (s-cMet) serum levels in childre...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2006
ISSN: 0959-9673
DOI: 10.1111/j.1365-2613.2006.00481.x